Biotinylated Human IL-28 R alpha Protein, His,Avitag™

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Qty.
ILR-H82E4-25ug
¥3675.00
ILR-H82E4-200ug
¥14490.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Interferon lambda receptor 1,IFN-lambda receptor 1,IFN-lambda-R1,Cytokine receptor class-II member 12,Cytokine receptor family 2 member 12,CRF2-12,Interleukin-28 receptor subunit alpha,IL-28 receptor subunit alpha,IL-28R-alpha,IL-28RA,Likely interleukin or cytokine receptor 2,LICR2,IFNLR1,IL28RA, LICR2

  • 表达区间及表达系统(Source)

    Biotinylated Human IL-28 R alpha Protein, His,Avitag (ILR-H82E4) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Ala 228 (Accession # Q8IU57-1).

    Predicted N-terminus: Arg 21

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-28 R alpha Structure

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 27.2 kDa. The protein migrates as 40-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 标记(Labeling)

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • 蛋白标记度(Protein Ratio)

    Passed as determined by the HABA assay / binding ELISA.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    IL-28 R alpha SDS-PAGE

    Biotinylated Human IL-28 R alpha Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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背景介绍

IL-28 R alpha (Interleukin-28 receptor subunit alpha) also known as IFNLR1 (IFN-lambda receptor 1), it heterodimerizes with another subunit, IL-10RB, to form a type II cytokine receptor ,which binds IL-28A, IL-28B and IL-29. These ligands, which are distantly related to class I in terferons, are activated upon viral infection and trigger the JAK-STAT signaling pathway to exert antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.

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