Human IL-28 R alpha / IFN-lambda R1 Protein, His Tag

用户评价
货号-规格
价格
Qty.
ILR-H52H9-100ug
¥3990.00
ILR-H52H9-1mg (500ug X 2)
¥26250.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Interferon lambda receptor 1,IFN-lambda receptor 1,IFN-lambda-R1,Cytokine receptor class-II member 12,Cytokine receptor family 2 member 12,CRF2-12,Interleukin-28 receptor subunit alpha,IL-28 receptor subunit alpha,IL-28R-alpha,IL-28RA,Likely interleukin or cytokine receptor 2,LICR2,IFNLR1,IL28RA, LICR2

  • 表达区间及表达系统(Source)

    Human IL-28 R alpha, His Tag (ILR-H52H9) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Ala 228 (Accession # Q8IU57-1).

    Predicted N-terminus: Arg 21

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-28 R alpha Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 25.5 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

推荐产品

数据展示

  • 电泳(SDS-PAGE)

    IL-28 R alpha SDS-PAGE

    Human IL-28 R alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

用户评价
发表评论

背景介绍

IL-28 R alpha (Interleukin-28 receptor subunit alpha) also known as IFNLR1 (IFN-lambda receptor 1), it heterodimerizes with another subunit, IL-10RB, to form a type II cytokine receptor ,which binds IL-28A, IL-28B and IL-29. These ligands, which are distantly related to class I in terferons, are activated upon viral infection and trigger the JAK-STAT signaling pathway to exert antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.

前沿进展

 
联系我们
项目合作
查看更多项目
实验案例分析
查看更多案例分析
  • 产品基础信息
  • 产品详情
  • 推荐产品
  • 数据展示
  • 用户评价
  • 背景介绍