Cynomolgus IL-23 R Protein, His Tag (MALS & SPR verified)

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ILR-C52H7-100ug
¥4200.00
ILR-C52H7-1mg
¥27300.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IL-23 R

  • 表达区间及表达系统(Source)

    Cynomolgus IL-23 R Protein, His Tag (ILR-C52H7) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Asp 353 (Accession # G7NWY5).

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-23 R Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 40.0 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    IL-23 R SDS-PAGE

    Cynomolgus IL-23 R Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-23 R SEC-MALS

    The purity of Cynomolgus IL-23 R Protein, His Tag (Cat. No. ILR-C52H7) is more than 85% and the molecular weight of this protein is around 50-70 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-SPR

     IL-23 R SPR

    Biotinylated Human IL-23 alpha&IL-12 beta Heterodimer Protein, His,Avitag&Tag Free (Cat. No. ILB-H82W6) captured on Biotin CAP-Series S Sensor Chip can bind Cynomolgus IL-23 R Protein, His Tag (Cat. No. ILR-C52H7) with an affinity constant of 49.2 nM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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背景介绍

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

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