Rat IL-22 Protein, His Tag (MALS & SPR verified)

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IL2-R52H6-50ug
¥3675.00
IL2-R52H6-1mg
¥27300.00
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产品详情

  • 分子别名(Synonym)

    IL-22, IL-TIF, ZCYTO18

  • 表达区间及表达系统(Source)

    Rat IL-22 Protein, His Tag (IL2-R52H6) is expressed from human 293 cells (HEK293). It contains AA Leu 34 - Val 179 (Accession # G3V6X6).

    Predicted N-terminus: Leu 34

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-22 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 18.5 kDa. The protein migrates as 27-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    IL-22 SDS-PAGE

    Rat IL-22 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-22 SEC-MALS

    The purity of Rat IL-22 Protein, His Tag (Cat. No. IL2-R52H6) is more than 90% and the molecular weight of this protein is around 20-30 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-SPR

     IL-22 SPR

    Mouse IL-22 R alpha 1 Protein, His Tag (Cat. No. IL1-M52H8) immobilized on CM5 Chip can bind Rat IL-22 Protein, His Tag (Cat. No. IL2-R52H6) with an affinity constant of 161 nM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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背景介绍

Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin-22

  • 中文全称:

    白细胞介素-22

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    3 详情

  • 最高研发阶段:

    临床三期

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