Biotinylated Human IL-21 R Protein, Fc,Avitag™ (MALS verified)

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ILR-H82F7-25ug
¥3675.00
ILR-H82F7-200ug
¥14490.00
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产品详情

  • 分子别名(Synonym)

    IL21R,CD360,NILR

  • 表达区间及表达系统(Source)

    Biotinylated Human IL-21 R Protein, Fc,Avitag (ILR-H82F7) is expressed from human 293 cells (HEK293). It contains AA Cys 20 - Pro 236 (Accession # Q9HBE5-1).

    Predicted N-terminus: Cys 20

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-21 R Structure

    This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 53.1 kDa. The protein migrates as 65 -80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 标记(Labeling)

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • 蛋白标记度(Protein Ratio)

    Passed as determined by the HABA assay / binding ELISA.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    IL-21 R SDS-PAGE

    Biotinylated Human IL-21 R Protein, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-21 R SEC-MALS

    The purity of Biotinylated Human IL-21 R Protein, Fc,Avitag (Cat. No. ILR-H82F7) is more than 85% and the molecular weight of this protein is around 120-140 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     IL-21 R ELISA

    Immobilized Human IL-21, premium grade (Cat. No. IL1-H5213) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-21 R Protein, Fc,Avitag (Cat. No. ILR-H82F7) with a linear range of 2-39 ng/mL (QC tested).

    Protocol

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背景介绍

Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. IL21R contains two fibronectin type-III domains. IL21R is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin 21 Receptor

  • 中文全称:

    白介素21受体

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    2 详情

  • 最高研发阶段:

    临床一期

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