Human IL-20 R alpha Protein, Fc Tag (MALS & SPR verified)

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ILA-H525d-100ug
¥3675.00
ILA-H525d-1mg
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Interleukin-20 receptor subunit alpha, IL-20 receptor subunit alpha, IL-20R-alpha, IL-20RA, Cytokine receptor class-II member 8, Cytokine receptor family 2 member 8, CRF2-8, IL-20R1, ZcytoR7

  • 表达区间及表达系统(Source)

    Human IL-20 R alpha, Fc Tag (ILA-H525d) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Lys 250 (Accession # Q9UHF4-1).

    Predicted N-terminus: Val 30

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-20 R alpha Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 51.7 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    IL-20 R alpha SDS-PAGE

    Human IL-20 R alpha, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    IL-20 R alpha SEC-MALS

    The purity of Human IL-20 R alpha, Fc Tag (Cat. No. ILA-H525d) is more than 95% and the molecular weight of this protein is around 114-140 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-SPR

     IL-20 R alpha SPR

    Human IL-20, His Tag (Cat. No. IL0-H5243) immobilized on CM5 Chip can bind Human IL-20 R alpha, Fc Tag (Cat. No. ILA-H525d) with an affinity constant of 4.42 μM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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背景介绍

The IL-20 receptor alpha subunit forms a functional heterodimer with the IL-20 beta subunit, and transduces ligand-binding at least in part through STAT3 activation.The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

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