Human IL-17 RB Protein, Fc Tag

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货号-规格
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Qty.
ILB-H5251-100ug
¥3675.00
ILB-H5251-1mg
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IL-17 RB, Interleukin-17 receptor B, Interleukin-17 receptor B, Cytokine receptor-like 4, IL-17 receptor homolog 1, IL-17Rh1, IL17Rh1, Interleukin-17B receptor, IL-17B receptor, IL17RB, CRL4, EVI27, IL17BR

  • 表达区间及表达系统(Source)

    Human IL-17 RB, Fc Tag (ILB-H5251) is expressed from human 293 cells (HEK293). It contains AA Arg 18 - Pro 292 (Accession # Q9NRM6-1).

    Predicted N-terminus: Arg 18

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-17 RB Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 56.7 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris,100 mM Glycine,25 mM Arginine,150 mM NaCl,pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    IL-17 RB SDS-PAGE

    Human IL-17 RB, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • 活性(Bioactivity)-ELISA

     IL-17 RB ELISA

    Immobilized Human IL-17 RB, Fc Tag (Cat. No. ILB-H5251) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-17E Protein, His,Avitag (Cat. No. IL5-H82E1) with a linear range of 0.08-5 ng/mL (QC tested).

    Protocol
  •  IL-17 RB ELISA

    Immobilized Human IL-17 RB, Fc Tag (Cat. No. ILB-H5251) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse IL-17E Protein, His,Avitag (Cat. No. ILE-M82E3) with a linear range of 0.06-2 ng/mL (Routinely tested).

    Protocol
  •  IL-17 RB ELISA

    Immobilized Human IL-17 RB, Fc Tag (Cat. No. ILB-H5251) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-17B, Fc,Avitag (Cat. No. ILB-H82F1) with a linear range of 0.005-5 μg/mL (Routinely tested).

    Protocol

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背景介绍

IL17RB (EVI27, IL17Rh1) is a single pass transmembrane receptor which belongs to IL17R family of cytokine receptors. It was found to be expressed in liver, brain, testis and lungs. The ligand for IL17RB is IL17E, also known as IL25. The five IL-17 receptors (IL17RA-IL17RE) exhibit considerable sequence divergence between one another, but all appear to contain extracellular domains composed of fibronectin type-III (FnIII) domains, and cytoplasmic SEF/IL-17R (SEFIR) domains that show loose homology to Toll/IL-1R (TLR) domains.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin-17 receptor B

  • 中文全称:

    白细胞介素-17受体B

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床一期

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