Mouse IL-11 R alpha Protein, His Tag

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ILR-M52H9-100ug
¥4045.00
ILR-M52H9-1mg (500ug X 2)
¥25470.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IL-11 R alpha,IL-11 RA,IL11RA,Interleukin-11 receptor subunit alpha,IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha

  • 表达区间及表达系统(Source)

    Mouse IL-11 R alpha, His Tag (ILR-M52H9) is expressed from human 293 cells (HEK293). It contains AA Cys 26 - Gln 367 (Accession # Q64385-1).

    Predicted N-terminus: Cys 26

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-11 R alpha Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 38.0 kDa. The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    IL-11 R alpha SDS-PAGE

    Mouse IL-11 R alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • 活性(Bioactivity)-ELISA

     IL-11 R alpha ELISA

    Immobilized Human IL-11, Fc Tag (Cat. No. IL1-H5269) at 5 μg/mL (100 μL/well) can bind Mouse IL-11 R alpha, His Tag (Cat. No. ILR-M52H9) with a linear range of 0.005-0.156 μg/mL (QC tested).

    Protocol
  •  IL-11 R alpha ELISA

    Immobilized Mouse IL-11 R alpha, His Tag (Cat. No. ILR-M52H9) at 5 μg/mL (100 μL/well) can bind Mouse IL-11 Protein, Fc Tag (Cat. No. IL1-M5243) with a linear range of 0.2-10 ng/mL ng/mL (Routinely tested).

    Protocol

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背景介绍

Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin 11 receptor alpha

  • 中文全称:

    白细胞介素-11受体α

  • 种类:

  • 上市药物数量:

    9 详情

  • 临床药物数量:

    3 详情

  • 最高研发阶段:

    批准上市

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