Biotinylated Mouse IL-1 alpha / IL-1F1 Protein, His,Avitag™ (MALS verified)

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ILA-M82E8-25ug
¥3675.00
ILA-M82E8-200ug
¥14490.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IL1A, IL-1 ALPHA, IL1F1, IL1α

  • 表达区间及表达系统(Source)

    Biotinylated Mouse IL-1 alpha, His,Avitag (ILA-M82E8) is expressed from human 293 cells (HEK293). It contains AA Ser 115 - Ser 270 (Accession # P01582-1).

    Predicted N-terminus: Ser 115

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-1 alpha Structure

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 21.6 kDa. The protein migrates as 27-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 标记(Labeling)

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • 蛋白标记度(Protein Ratio)

    Passed as determined by the HABA assay / binding ELISA.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    IL-1 alpha SDS-PAGE

    Biotinylated Mouse IL-1 alpha, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    IL-1 alpha SEC-MALS

    The purity of Biotinylated Mouse IL-1 alpha, His,Avitag (Cat. No. ILA-M82E8) is more than 95% and the molecular weight of this protein is around 21-31 kDa verified by SEC-MALS.

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背景介绍

Interleukin-1 alpha (IL1a) is also known as IL-1A, IL1, IL1-ALPHA,IL1F1,and is a cytokine of the interleukin-1 family. IL1a possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. IL-1α is constitutively produced by epithelial cells. It is found in substantial amounts in normal human epidermis and is distributed in a 1:1 ratio between living epidermal cells and stratum corneum.The constitutive production of large amounts of IL-1α precursor by healthy epidermal keratinocytes interfere with the important role of IL-1α in immune responses, assuming skin as a barrier, which prevents the entry of pathogenic microorganisms into the body. In vitro, IL-1α possesses biological effect on cells in the picomolar to femtomolar range. In vivo, Shortly after an onset of an infection into organism, IL-1α activates a set of immune system response processes.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin-1 alpha

  • 中文全称:

    白细胞介素-1α

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    7 详情

  • 最高研发阶段:

    批准上市

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