Human IFN-alpha 2a (R46K) Protein, Fc Tag (MALS verified)

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IFA-H5253-100ug
¥3675.00
IFA-H5253-1mg (500ug X 2)
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IFN-alpha 2a, IFNA2a, IFN-alpha 2 (alpha 2a), interferon alpha 2a

  • 表达区间及表达系统(Source)

    Human IFN-alpha 2a (R46K) Protein, Fc Tag (IFA-H5253) is expressed from human 293 cells (HEK293). It contains AA Cys 24 - Glu 188 (R46K) (Accession # P01563 (R46K)).

    Predicted N-terminus: Cys 24

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IFN-alpha 2a Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 45.7 kDa. The protein migrates as 48-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    IFN-alpha 2a SDS-PAGE

    Human IFN-alpha 2a (R46K) Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IFN-alpha 2a SEC-MALS

    The purity of Human IFN-alpha 2a (R46K) Protein, Fc Tag (Cat. No. IFA-H5253) is more than 95% and the molecular weight of this protein is around 90-110 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     IFN-alpha 2a ELISA

    Immobilized Human IFNAR2, His Tag (Cat. No. IF2-H5224) at 5 μg/mL (100 μL/well) can bind Human IFN-alpha 2a (R46K) Protein, Fc Tag (Cat. No. IFA-H5253) with a linear range of 1-40 ng/mL (QC tested).

    Protocol

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背景介绍

IFN-alpha is a cytokine that has an immunomodulatory function. It plays an important role not only in antiviral activity but also in several physiologic functions, such as activation of dendritic cells and accelerated expression of major histocompatibility complex I and II molecules that may cause increased antigen presentation. Variants of human leukocyte interferon alpha 2 (IFN-alpha 2a, alpha 2b, and alpha 2c) differ from each other by changes in their coding regions at nucleotide positions 137 and 170. IFN-alpha 2b (IFNα-2b) is an important cytokine and used for antiviral and anticancer treatment.

前沿进展

 
药物研发进展
  • 英文全称:

    Interferon alpha 2a

  • 中文全称:

    干扰素α-2a

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    0 详情

  • 最高研发阶段:

    临床前

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