Human HTT Protein, MBP,His Tag (MALS verified)

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货号-规格
价格
Qty.
HTT-H51M5-25ug
¥1090.00
HTT-H51M5-100ug
¥2730.00
HTT-H51M5-500ug
¥8190.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    HTT, Htt, Huntingtin

  • 表达区间及表达系统(Source)

    Human HTT, MBP,His Tag (HTT-H51M5) is expressed from E. coli cells. It contains AA Met 1 - Glu 82 (Accession # P42858-1).

    Predicted N-terminus: Met

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    HTT Structure

    This protein carries a MBP tag at the N-terminus and a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 52.7 kDa. The protein migrates as 60-63 kDa under reducing (R) condition (SDS-PAGE).

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 20 mM HEPES, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    HTT SDS-PAGE

    Human HTT, MBP,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    HTT SEC-MALS

    The purity of Human HTT, MBP,His Tag (Cat. No. HTT-H51M5) is more than 85% and the molecular weight of this protein is around 62-80 kDa verified by SEC-MALS.

    Report

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背景介绍

Huntingtin is the protein coded for by the HTT gene. Autosomal dominant mutation in the Huntingtin (Htt) protein is the cause of Huntington’s Disease (HD). In HD, the polyglutamine (polyQ) domain in the N-terminal sequenceof the protein is expanded beyond a threshold of 36 glutamines. mutant polyQ expansion strongly correlates in an inverse manner to disease age of onset.

前沿进展

 
药物研发进展
  • 英文全称:

    Huntingtin

  • 中文全称:

    亨廷顿蛋白

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    7 详情

  • 最高研发阶段:

    临床三期

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