APC-Labeled Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Tetramer Protein

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HLT-HA2H7-25ug
¥4160.00
HLT-HA2H7-200ug (50ug X 4)
¥23940.00
合计0件 产品金额¥ 0

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  • 分子别名(Synonym)

    HLA-A*0201 & B2M & hTERT (ILAKFLHWL)

  • 表达区间及表达系统(Source)

    APC-Labeled Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Tetramer Protein (HLT-HA2H7) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & ILAKFLHWL peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & ILAKFLHWL).

    Predicted N-terminus: Gly 25 & Ile 21

  • 蛋白结构(Molecular Characterization)

    APC-Labeled Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Tetramer Protein is assembled by biotinylated monomer and APC-labeled streptavidin.

    Biotinylated Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Complex Protein is produced by co-expression of HLA and B2M loaded with hTERT peptide. Biotinylated Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

  • 偶联(Conjugate)

    APC

    Excitation Wavelength: 640 nm

    Emission Wavelength: 661 nm

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 1% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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背景介绍

hTERT (human Telomerase Reverse Transcriptase), the catalytic subunit of telomerase, maintains telomere length to drive tumor cells’ unlimited proliferation. It is highly expressed in ~85-90% of cancers but silenced in most normal somatic cells. The peptide ILAKFLHWL (from hTERT residues 540-548) acts as a tumor-specific antigen. It binds to MHC class I molecule HLA-A0201 to form a surface complex on tumors, activating cytotoxic T lymphocytes (CTLs). The Human HLA-A*0201 hTERT (ILAKFLHWL) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and ILAKFLHWL peptide of the hTERT.

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