Mouse Glypican 1 / GPC1 Protein, His Tag

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GP1-M52H7-100ug
¥3980.00
GP1-M52H7-1mg (500ug X 2)
¥24255.00
合计0件 产品金额¥ 0

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  • 分子别名(Synonym)

    Glypican 1,GPC1

  • 表达区间及表达系统(Source)

    Mouse Glypican 1, His Tag (GP1-M52H7) is expressed from human 293 cells (HEK293). It contains AA Asp 24 - Ser 529 (Accession # Q9QZF2-1).

    Predicted N-terminus: Asp 24

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Glypican 1 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 57.5 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    Glypican 1 SDS-PAGE

    Mouse Glypican 1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • 活性(Bioactivity)-ELISA

     Glypican 1 ELISA

    Immobilized Human FGF basic, premium grade (Cat. No. BFF-H4117) at 1 μg/mL (100 μL/well) can bind Mouse Glypican 1, His Tag (Cat. No. GP1-M52H7) with a linear range of 5-78 ng/mL (QC tested).

    Protocol

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背景介绍

Glypican 1 has been shown to interact with SLIT2. This protein is involved in the misfolding of normal prion proteins in the cell membrane to the infectious prion form. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

前沿进展

 
药物研发进展
  • 英文全称:

    Glypican-1

  • 中文全称:

    磷脂酰肌醇聚糖1

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床一期

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