Human Glucosylceramidase Protein, His Tag

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货号-规格
价格
Qty.
GLE-H52H3-20ug
¥3255.00
GLE-H52H3-100ug
¥10080.00
GLE-H52H3-1mg
¥60900.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Glucosylceramidase,GBA,Acid beta-glucosidase,Alglucerase,beta-glucocerebrosidase,D-glucosyl-N-acylsphingosine glucohydrolase,EC 3.2.1.45,GBA,GBA1,GC,GCB,GLUC,glucosidase, beta, acid,glucosidase, beta,acid (includes glucosylceramidase),Glucosylceramidase,Imiglucerase,lysosomal glucocerebrosidase

  • 表达区间及表达系统(Source)

    Human Glucosylceramidase, His Tag (GLE-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 40 - Gln 536 (Accession # P04062-1).

    Predicted N-terminus: Ala 40

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Glucosylceramidase Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 57.5 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Supplied as 0.2 μm filtered solution in 0.1 M Sodium citrate, pH5.5 with Glycerol as protectant.

    Contact us for customized product form or formulation.

  • 运输(Shipping)

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储(Storage)

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    Glucosylceramidase SDS-PAGE

    Human Glucosylceramidase, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

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背景介绍

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, it plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides,it participates in the PKC-activated salvage pathway of ceramide formation and plays a role in cholesterol metabolism. It may either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. Defects in Glucosylceramidase are the cause of Gaucher disease, also known as glucocerebrosidase deficiency. Gaucher disease is the most prevalent lysosomal storage disease, characterized by accumulation of glucosylceramide in the reticulo-endothelial system. Currently, enzyme replacement therapy is used to treat patients with the disease.

前沿进展

 
药物研发进展
  • 英文全称:

    Glucosylceramidase

  • 中文全称:

    葡糖苷酰鞘氨醇酶

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床一期

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