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Human GLP1R Full Length Protein (VLP)

COADS MS
DS
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GLR-H52P3-20ug
¥5250.00
GLR-H52P3-100ug
¥10500.00
GLR-H52P3-500ug (250ug X 2)
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产品详情

  • 分子别名（Synonym）

    GLP-1-R, GLP-1R, glucagon like peptide 1 receptor

  • 表达区间及表达系统（Source）

    Human GLP1R Full Length Protein (VLP) (GLR-H52P3) is expressed from human 293 cells (HEK293). It contains AA Arg 24 - Ser 432 (Accession # P43220-1).

    Predicted N-terminus: Asp

  • 蛋白结构（Molecular Characterization）

    Virus-like particles(VLPs) are formed by self-assembly of capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.

    The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 制剂（Formulation）

    The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

    Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程
  • *The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow this link for product information.

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数据展示

  • 活性（Bioactivity）-ELISA

    GLP1R ELISA

    Immobilized Human GLP1R Full Length Protein (VLP) (Cat. No. GLR-H52P3) at 5 μg/mL (100 μL/well) can bind Anti-GLP1R antibody, Human IgG2 with a linear range of 0.05-3 ng/mL (QC tested).

    Protocol

  • 均一性（Identity）-DLS

    GLP1R DLS

    The mean peak Radius of VLP is 55-75 nm with more than 95% intensity as determined by dynamic light scattering (DLS).

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背景介绍

GLP-1R (Glucagon-Like Peptide-1 Receptor) is a type of G-protein-coupled receptor (GPCR) that plays a crucial role in metabolic regulation, and its specific ligand is glucagon-like peptide-1 (GLP-1). The binding of GLP-1 to GLP-1R induces a conformational change in the receptor, subsequently triggering downstream signaling cascades. These cascades further activate adenylyl cyclase, ultimately leading to an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. Studies have demonstrated that GLP-1R can regulate insulin secretion in response to GLP-1 through the aforementioned pathway (By similarity), which is of great significance for maintaining systemic glucose homeostasis.

前沿进展

 
药物研发进展
  • 英文全称：

    Glucagon-like peptide-1

  • 中文全称：

    胰高血糖素类肽-1

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    5 详情

  • 最高研发阶段：

    临床三期

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