Human GAS6 (471-678) Protein, His Tag (MALS verified)

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GA6-H5247-100ug
¥4045.00
GA6-H5247-1mg (500ug X 2)
¥26680.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    GAS6, GAS-6, AXLLG

  • 表达区间及表达系统(Source)

    Human GAS6 (471-678) Protein, His Tag (GA6-H5247) is expressed from human 293 cells (HEK293). It contains AA Phe 471 - Ala 678 (Accession # Q14393-2).

    Predicted N-terminus: His

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    GAS6 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 24.5 kDa. The protein migrates as 26-27 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    GAS6 SDS-PAGE

    Human GAS6 (471-678) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    GAS6 SEC-MALS

    The purity of Human GAS6 (471-678) Protein, His Tag (Cat. No. GA6-H5247) is more than 90% and the molecular weight of this protein is around 20-30 kDa verified by SEC-MALS.

    Report

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背景介绍

GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG. Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

前沿进展

 
药物研发进展
  • 英文全称:

    Growth arrest-specific protein 6

  • 中文全称:

    生长停滞特异性蛋白6

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床三期

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