Human Galectin-9 / LGALS9 Protein, Tag Free (MALS verified)

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LG9-H5213-100ug
¥4800.00
LG9-H5213-1mg
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Galectin-9, LGALS9, Ecalectin

  • 表达区间及表达系统(Source)

    Human Galectin-9 Protein, Tag Free (LG9-H5213) is expressed from human 293 cells (HEK293). It contains AA Ala 2 - Thr 323 (Accession # O00182-2).

    Predicted N-terminus: His

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Galectin-9 Structure

    This protein carries no "tag".

    The protein has a calculated MW of 38.5 kDa. The protein migrates as 43-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 20 mM MOPS, 50 mM NaCl, pH7.3 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    Galectin-9 SDS-PAGE

    Human Galectin-9 Protein, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Galectin-9 SEC-MALS

    The purity of Human Galectin-9 Protein, Tag Free (Cat. No. LG9-H5213) is more than 90% and the molecular weight of this protein is around 45-65 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     Galectin-9 ELISA

    Immobilized Human Galectin-9 Protein, Tag Free (Cat. No. LG9-H5213) at 1 μg/mL (100 μL/well) can bind Anti-Gal9 Antibody with a linear range of 0.06-4 ng/mL (QC tested).

    Protocol

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背景介绍

Galectin-9 (LGALS9) is also known as tumor antigen HOM-HD-21 and ecalectin. Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. As for Galectin-9, it has high affinity for the Forssman pentasaccharide, and it is also the ligand for HAVCR2/TIM3. Forthermore, Galectin-9 stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.

前沿进展

 
药物研发进展
  • 英文全称:

    Galactoside-binding lectin Galectin 9

  • 中文全称:

    半乳糖凝集素-9

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    2 详情

  • 最高研发阶段:

    临床二期

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