pHERV-W Envelope protein, His Tag

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货号-规格
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Qty.
ENN-V5243-100ug
¥3360.00
ENN-V5243-1mg
¥21840.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Envelope protein, Env polyprotein, Envelope glycoprotein, env

  • 表达区间及表达系统(Source)

    pHERV-W Envelope protein, His Tag (ENN-V5243) is expressed from human 293 cells (HEK293). It contains AA Ser 30 - Lys 316 (Accession # AAK18189.1).

    Predicted N-terminus: His

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Envelope protein Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 33.9 kDa. The protein migrates as 48-58 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    Envelope protein SDS-PAGE

    pHERV-W Envelope protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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背景介绍

Dengue virus envelope (E) glycoprotein is a class II fusion protein mediating viral attachment and entry. Organized as dimers on the virion surface, it binds host receptors and, upon endosomal acidification, undergoes dramatic conformational rearrangements to drive membrane fusion. Structurally, E comprises three domains (DI, DII, DIII), with DIII responsible for receptor recognition. Highly immunogenic, E elicits neutralizing antibodies and is the principal target for vaccine design and therapeutic antibody development, as inhibiting its fusogenic transition blocks dengue virus infection.

前沿进展

 
药物研发进展
  • 英文全称:

    Recombinant envelope protein

  • 中文全称:

    重组包膜蛋白

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    5 详情

  • 最高研发阶段:

    批准上市

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