Mouse Complement C3 Protein, His Tag (MALS verified)

用户评价
货号-规格
价格
Qty.
CO3-M52H4-100ug
¥4045.00
CO3-M52H4-1mg
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Complement C3,CPAMD1

  • 表达区间及表达系统(Source)

    Mouse Complement C3, His Tag (CO3-M52H4) is expressed from human 293 cells (HEK293). It contains AA Ile 25 - Asn 1663 (Accession # P01027-1).

    Predicted N-terminus: Ile 25

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Complement C3 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 186.1 kDa. The protein migrates as 70 kDa, 100-120 kDa and 160-180 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

推荐产品

数据展示

  • 电泳(SDS-PAGE)

    Complement C3 SDS-PAGE

    Mouse Complement C3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    Complement C3 SEC-MALS

    The purity of Mouse Complement C3, His Tag (Cat. No. CO3-M52H4) is more than 90% and the molecular weight of this protein is around 167-204 kDa verified by SEC-MALS.

    Report

用户评价
发表评论

背景介绍

C3 is the major complement component serum. It is mainly synthesized by macrophages and liver. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. It is cleaved into two fragments, C3a and C3b. C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

前沿进展

 
药物研发进展
  • 英文全称:

    Complement C3

  • 中文全称:

    补体C3

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    13 详情

  • 最高研发阶段:

    批准上市

联系我们
项目合作
查看更多项目
实验案例分析
查看更多案例分析
  • 产品基础信息
  • 产品详情
  • 推荐产品
  • 数据展示
  • 用户评价
  • 背景介绍