Human CLEC4C / BDCA2 Protein, Fc Tag

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CLC-H5254-100ug
¥3675.00
CLC-H5254-1mg
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    DLEC,CLEC4C,BDCA-2,CD303,CLECSF11,CLECSF7, HECL

  • 表达区间及表达系统(Source)

    Human CLEC4C, Fc Tag (CLC-H5254) is expressed from human 293 cells (HEK293). It contains AA Asn 45 - Ile 213 (Accession # Q8WTT0-1).

    Predicted N-terminus: Pro

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CLEC4C Structure

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 46.4 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    CLEC4C SDS-PAGE

    Human CLEC4C, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

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背景介绍

CLEC4C (C-type lectin domain family 4 member C), also known as BDCA2, CLECSF11, CLECSF7, DLEC and CD303. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cell. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.

前沿进展

 
药物研发进展
  • 英文全称:

    C-Type lectin domain family 4 member C

  • 中文全称:

    C型凝集素结构域家族4成员C

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    5 详情

  • 最高研发阶段:

    临床三期

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