Rhesus macaque CD89 / FCAR Protein, His Tag (MALS verified)

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CD9-R52H5-25ug
¥2200.00
CD9-R52H5-200ug
¥8800.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CD89,FCAR,IgA Fc receptor

  • 表达区间及表达系统(Source)

    Rhesus macaque CD89 Protein, His Tag (CD9-R52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Asn 227 (Accession # F7H5K2-1).

    Predicted N-terminus: Gln 22

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CD89 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 25.2 kDa. The protein migrates as 45-58 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    CD89 SDS-PAGE

    Rhesus macaque CD89 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD89 SEC-MALS

    The purity of Rhesus macaque CD89 Protein, His Tag (Cat. No. CD9-R52H5) is more than 90% and the molecular weight of this protein is around 39-55 kDa verified by SEC-MALS.

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背景介绍

CD89 (FcαRI), encoded by the FCAR gene, is an IgA-specific receptor primarily expressed on myeloid cells (e.g., neutrophils, monocytes/macrophages). It mediates immune defense functions by binding to the Fc region of IgA (with a preference for polymeric forms), facilitating phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and inflammation regulation. Its signaling relies on the ITAM motif of the FcRγ chain, enabling dual immunoregulatory roles in both activation and suppression. Clinically, CD89 is implicated in IgA nephropathy, pathogen immune evasion, and tumor immunity. Targeted therapies, such as the bispecific antibody MOR202, are under development for diseases like multiple myeloma, highlighting its therapeutic potential as a bridge between mucosal and systemic immunity.

前沿进展

 
药物研发进展
  • 英文全称:

    IgA Fc receptor

  • 中文全称:

    免疫球蛋白αFc受体

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床一期

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