Biotinylated Human CD6 / TP120 Protein, Fc,Avitag™ (MALS verified)

用户评价
货号-规格
价格
Qty.
CD6-H82F3-25ug
¥3675.00
CD6-H82F3-200ug
¥15960.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CD6, TP120, T12

  • 表达区间及表达系统(Source)

    Biotinylated Human CD6 Protein, Fc,Avitag (CD6-H82F3) is expressed from human 293 cells (HEK293). It contains AA His 18 - Glu 398 (Accession # P30203-1).

    Predicted N-terminus: His 18

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CD6 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 68.7 kDa. The protein migrates as 90-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 标记(Labeling)

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • 蛋白标记度(Protein Ratio)

    Passed as determined by the HABA assay / binding ELISA.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

推荐产品

数据展示

  • 电泳(SDS-PAGE)

    CD6 SDS-PAGE

    Biotinylated Human CD6 Protein, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD6 SEC-MALS

    The purity of Biotinylated Human CD6 Protein, Fc,Avitag (Cat. No. CD6-H82F3) is more than 90% and the molecular weight of this protein is around 185-220 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     CD6 ELISA

    Immobilized Human ALCAM, His Tag (Cat. No. CD6-H5228) at 5 μg/mL (100 μL/well) can bind Biotinylated Human CD6 Protein, Fc,Avitag (Cat. No. CD6-H82F3) with a linear range of 0.01-0.313 μg/mL (QC tested).

    Protocol

用户评价
发表评论

背景介绍

CD6 is a type 1 transmembrane glycoprotein with three extracellular SRCR domains that functions as a co-stimulatory receptor in T cell activation. Its primary ligand is CD166 (ALCAM), an IgSF member expressed on antigen-presenting cells and other tissues. CD6's long cytoplasmic tail contains tyrosine residues that, upon phosphorylation, recruit signaling molecules like SLP76 and SHP1. The CD6-ALCAM interaction promotes T cell activation and downstream MAPK signaling, influencing proliferation, differentiation, and survival. Importantly, CD6 regulates effector T cell (Teff) activity and trafficking, making it a key checkpoint in autoimmunity. Blocking the CD6-ALCAM pathway selectively inhibits pathogenic Teff cells while preserving Treg function, offering a potential therapeutic strategy for autoimmune diseases.

前沿进展

 
药物研发进展
  • 英文全称:

    T-cell differentiation antigen CD6

  • 中文全称:

    T细胞分化抗原CD6

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    0 详情

  • 最高研发阶段:

    批准上市

联系我们
项目合作
查看更多项目
实验案例分析
查看更多案例分析
  • 产品基础信息
  • 产品详情
  • 推荐产品
  • 数据展示
  • 用户评价
  • 背景介绍