Mouse CD38 Protein, His Tag (MALS verified)

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CD8-M5223-100ug
¥3675.00
CD8-M5223-1mg (250ug X 4)
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CD38, T10, cADPr hydrolase 1

  • 表达区间及表达系统(Source)

    Mouse CD38, His Tag (CD8-M5223) is expressed from human 293 cells (HEK293). It contains AA Leu 45 - Thr 304 (Accession # P56528-1).

    Predicted N-terminus: Leu 45

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CD38 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 31.7 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a dimer.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM MES, 100 mM NaCl, pH6.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    CD38 SDS-PAGE

    Mouse CD38, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    CD38 SEC-MALS

    The purity of Mouse CD38, His Tag (Cat. No. CD8-M5223) is more than 95% and the molecular weight of this protein is around 80-105 kDa verified by SEC-MALS.

    Report

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背景介绍

CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.

前沿进展

 
药物研发进展
  • 英文全称:

    Lymphocyte differentiation antigen CD38

  • 中文全称:

    淋巴细胞分化抗原CD38

  • 种类:

  • 上市药物数量:

    3 详情

  • 临床药物数量:

    40 详情

  • 最高研发阶段:

    临床三期

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