Human CD300a / LMIR1 Protein, His Tag (MALS verified)

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Qty.
CDA-H52H5-1mg (500ug X 2)
¥24255.00
CDA-H52H5-100ug
¥3860.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CD300A,CLM-8,CMRF-35-H9,CMRF35-H9,CMRF35-H,IRC1,IRC2,IgSF12,IRp60,CMRF35H,IGSF12,LMIR1

  • 表达区间及表达系统(Source)

    Human CD300a Protein, His Tag (CDA-H52H5) is expressed from human 293 cells (HEK293). It contains AA Leu 18 - Ser 128 (Accession # Q9UGN4-1).

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  • 蛋白结构(Molecular Characterization)

    CD300a Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 14.4 kDa. The protein migrates as 16 kDa and 19-26 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    CD300a SDS-PAGE

    Human CD300a Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD300a SEC-MALS

    The purity of Human CD300a Protein, His Tag (Cat. No. CDA-H52H5) is more than 85% and the molecular weight of this protein is around 16-24 kDa verified by SEC-MALS.

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背景介绍

CD300a, expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6.

前沿进展

 
药物研发进展
  • 英文全称:

    CMRF35-like molecule 8

  • 中文全称:

  • 种类:

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  • 临床药物数量:

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  • 最高研发阶段:

    临床前

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