Biotinylated Mouse CD200 / OX-2 Protein, Fc,Avitag™ (MALS verified)

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OX2-M82F3-25ug
¥3675.00
OX2-M82F3-200ug
¥14490.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CD200, MOX1, MOX2, MRC, OX-2, My033

  • 表达区间及表达系统(Source)

    Biotinylated Mouse CD200, Fc,Avitag (OX2-M82F3) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gly 232 (Accession # O54901-1).

    Predicted N-terminus: Gln 31

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CD200 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 50.5 kDa. The protein migrates as 66-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 标记(Labeling)

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • 蛋白标记度(Protein Ratio)

    Passed as determined by the HABA assay / binding ELISA.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    CD200 SDS-PAGE

    Biotinylated Mouse CD200, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    CD200 SEC-MALS

    The purity of Biotinylated Mouse CD200, Fc,Avitag (Cat. No. OX2-M82F3) is more than 95% and the molecular weight of this protein is around 125-135 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     CD200 ELISA

    Immobilized Human CD200 R1, His Tag (Cat. No. CR2-H52H6) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse CD200, Fc,Avitag (Cat. No. OX2-M82F3) with a linear range of 0.02-0.5 μg/mL (QC tested).

    Protocol

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背景介绍

CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

前沿进展

 
药物研发进展
  • 英文全称:

    OX-2 membrane glycoprotein

  • 中文全称:

    OX-2膜糖蛋白

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床二期

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