选择语言
免费注册
关注公众号
微信客服
收藏产品

Cynomolgus CD117 / c-kit (D198E) Protein, His Tag (MALS verified)

COADS MS
DS
用户评价
货号-规格
价格
Qty.
CD7-C52H4-200ug
¥6300.00
合计0件 产品金额¥ 0
新品建议
增项建议

产品详情

  • 分子别名（Synonym）

    CD117, SCFR, c-Kit, KIT

  • 表达区间及表达系统（Source）

    Cynomolgus CD117 (D198E) Protein, His Tag (CD7-C52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Pro 524 (Accession # A0A2K5U4C5 (D198E)).

    Predicted N-terminus: Gln 26

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    CD117 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 57.9 kDa. The protein migrates as 75-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 纯度（Purity）

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

推荐产品

数据展示

  • 电泳（SDS-PAGE）

    CD117 SDS-PAGE

    Cynomolgus CD117 (D198E) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD117 SEC-MALS

    The purity of Cynomolgus CD117 (D198E) Protein, His Tag (Cat. No. CD7-C52H4) is more than 90% and the molecular weight of this protein is around 70-100 kDa verified by SEC-MALS.

    Report

用户评价
发表评论

背景介绍

This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]

前沿进展

 
药物研发进展
  • 英文全称：

    Stem cell growth factor receptor

  • 中文全称：

    干细胞生长因子受体

  • 种类：

  • 上市药物数量：

    16 详情

  • 临床药物数量：

    32 详情

  • 最高研发阶段：

    申请上市

联系我们
项目合作
查看更多项目
实验案例分析
查看更多案例分析
  • 产品基础信息
  • 产品详情
  • 推荐产品
  • 数据展示
  • 用户评价
  • 背景介绍