Human CCR8 Full Length Protein, His,Flag Tag (Nanodisc-pro)

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CC8-H52D4-20ug
¥ 6240.00
CC8-H52D4-100ug
¥ 12480.00
CC8-H52D4-500ug
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合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CC chemokine receptor 8, CD198, ChemR1, CKRL1, CKR-L1, CKRL1, CY6, GPRCL1, GPRCY6, GPR-CY6, TER-1

  • 表达区间及表达系统(Source)

    Human CCR8 Full Length Protein, His,Flag Tag (CC8-H52D4) is expressed from human 293 cells (HEK293). It contains AA Asp 2 - Ser 345 (Accession # P51685-1 ).

  • 蛋白结构(Molecular Characterization)

    CCR8 Structure

    Nanodiscs are a new class of model membranes that are being used to solubilize and study a range of integral membrane proteins and membrane-associated proteins. The Nanodisc bilayer is bounded by an amphipathic scaffold coat that confers enhanced stability and a narrow particle size distribution.

    The nanodisc-pro is directly extracted from cell membrane in a water-soluble form using an amphipathic scaffold followed by affinity chromatography, and thus, it conserves a patch of native membrane around them.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 制剂(Formulation)

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • 运输(Shipping)

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储(Storage)

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程
  • *The isotype control of empty/mock nanodisc (Cat. No. APO-H5143) is sold separately and not included in protein, you can follow this link for product information.

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背景介绍

This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs). CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine). It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.

前沿进展

 
药物研发进展
  • 英文全称:

    C-C chemokine receptor type 8

  • 中文全称:

    CC趋化因子受体8型

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    14 详情

  • 最高研发阶段:

    临床二期

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