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Mouse CA125 / MUC16 Protein, His Tag (MALS verified)

COADS MS
DS
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货号-规格
价格
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CA5-M52H6-100ug
¥3675.00
CA5-M52H6-1mg (500ug X 2)
¥24255.00
合计0件 产品金额¥ 0
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产品详情

  • 分子别名（Synonym）

    CA125, CA-125, CA125MUC-16, FLJ14303, MUC16, mucin 16, mucin-16

  • 表达区间及表达系统（Source）

    Mouse CA125 Protein, His Tag (CA5-M52H6) is expressed from human 293 cells (HEK293). It contains AA Asn 7750 - Pro 8422 (Accession # A0A140LJ72-1).

    Predicted N-terminus: Asn 7750

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    CA125 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 76.7 kDa.

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度（Purity）

    >90% as determined by SEC-MALS.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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数据展示

  • SEC-MALS

    CA125 SEC-MALS

    The purity of Mouse CA125 Protein, His Tag (Cat. No. CA5-M52H6) is more than 90% and the molecular weight of this protein is around 120-140 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）-SPR

    CA125 SPR

    Biotinylated Mouse Mesothelin, His,Avitag (Cat. No. MSN-M82E7) immobilized on CM5 Chip can bind Mouse CA125 Protein, His Tag (Cat. No. CA5-M52H6) with an affinity constant of 16.4 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

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背景介绍

The CA125, also known as the MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. The CA 125 molecule is almost certainly a glycoprotein with a predominance of O-linkages. It is heterogeneous with regard to both size and charge, most likely due to continuous deglycosylation of side chains during its life-span in bodily fluids. It exists as a very large complex (perhaps as much as 4 million daltons) under natural conditions.

前沿进展

 
药物研发进展
  • 英文全称：

    Mucin-16

  • 中文全称：

    粘蛋白-16

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    7 详情

  • 最高研发阶段：

    临床三期

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