Human BMPR-1A / ALK-3 Protein, Fc Tag

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货号-规格
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Qty.
AL3-H5259-200ug
¥2520.00
AL3-H5259-1mg
¥10395.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    BMPR-1A,ALK-3,ACVRLK3,CD292,SKR5

  • 表达区间及表达系统(Source)

    Human BMPR-1A, Fc Tag (AL3-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Arg 152 (Accession # P36894-1).

    Predicted N-terminus: Gln 24

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    BMPR-1A Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 40.3 kDa. The protein migrates as 56 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >98% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    BMPR-1A SDS-PAGE

    Human BMPR-1A, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 98%.

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背景介绍

The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.

前沿进展

 
药物研发进展
  • 英文全称:

    Bone morphogenetic protein receptor type-1A

  • 中文全称:

    1A型骨形态发生蛋白受体

  • 种类:

  • 上市药物数量:

    2 详情

  • 临床药物数量:

    2 详情

  • 最高研发阶段:

    批准上市

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