Human BMP-4 / BMP2B Protein, Research Grade
academia only

  • This product is specifically for academia customers.
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货号-规格
价格
Qty.
BM4-H5318-20ug
¥1380.00
BM4-H5318-50ug
¥3210.00
BM4-H5318-1mg (200ug X 5)
¥25880.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME

  • 表达区间及表达系统(Source)

    Human BMP-4 Protein, Research Grade (BM4-H5318) is expressed from CHO cells. It contains AA Ser 293 - Arg 408 (Accession # NP_001193.2).

    Predicted N-terminus: Ser 293

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    BMP-4 Structure

    This protein carries no "tag".

    The protein has a calculated MW of 13.1 kDa. The protein migrates as 21 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 20 mM Citric acid, pH2.2 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 24 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程
  • 质量说明(Quality Description)

    ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration before lyophilization. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
    ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.

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数据展示

  • 电泳(SDS-PAGE)

    BMP-4 SDS-PAGE

    Human BMP-4 Protein, Research Grade on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • 活性(Bioactivity)-CELL BASE

     BMP-4 CELL

    Human BMP-4 Protein, Research grade (Cat. No. BM4-H5318) stimulates Human BMP (Luc) HEK293 Reporter cells. The typical EC50 for this effect is 3.85 ng/mL (QC tested).

    Protocol

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背景介绍

Bone Morphogenetic Protein 4 (BMP4) is a member of growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. BMP-4 Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. BMP-4 can acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.

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