Human Betacellulin Protein, Research Grade
academia only

  • This product is specifically for academia customers.
用户评价
货号-规格
价格
Qty.
BEN-H5117-20ug
¥1350.00
BEN-H5117-50ug
¥3260.00
BEN-H5117-1mg (200ug X 5)
¥18870.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    betacellulin, BTC

  • 表达区间及表达系统(Source)

    Human Betacellulin Protein, Research Grade (BEN-H5117) is expressed from E. coli cells. It contains AA Asp 32 - Gln 118 (Accession # P35070-1).

    Predicted N-terminus: Met

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Betacellulin Structure

    This protein carries no "tag".

    The protein has a calculated MW of 9.9 kDa. The protein migrates as 14 kDa±3 kDa under reducing (R) condition, and 14 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE).

  • 内毒素(Endotoxin)

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 20 mM Citric acid, pH2.2 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 24 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程
  • 质量说明(Quality Description)

    ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration before lyophilization. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
    ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.

推荐产品

数据展示

  • 电泳(SDS-PAGE)

    Betacellulin SDS-PAGE

    Human Betacellulin Protein, Research Grade on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • 活性(Bioactivity)-CELL BASE

     Betacellulin CELL

    Human Betacellulin Protein, Research Grade (Cat. No. BEN-H5117) stimulates Human EGF R (Luc) HEK293 Reporter Cell. The specific activity of Human Betacellulin Protein, Research Grade is > 3.50 x 10^3 U/mg (QC tested).

    Protocol

用户评价
发表评论

背景介绍

Betacellulin (BTC) is a member of the epidermal growth factor family that is comprised of at least ten proteins including EGF, TGF-alpha, amphiregulin, HB-EGF, and the various heregulins. All of these cytokines are synthesized as transmembrane precursors and are characterized by the presence of one or more EGF structural units in their extracellular domain. Betacellulin is expressed predominantly in the human pancreas and induces the differentiation of a pancreatic acinar cell line (AR42J) into insulin-secreting cells, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture.

前沿进展

 
联系我们
项目合作
查看更多项目
实验案例分析
查看更多案例分析
  • 产品基础信息
  • 产品详情
  • 推荐产品
  • 数据展示
  • 用户评价
  • 背景介绍