Human BDNF / Abrineurin Protein (E. coli), Research Grade
academia only

  • This product is specifically for academia customers.
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价格
Qty.
BDF-H5117-20ug
¥2120.00
BDF-H5117-50ug
¥3820.00
BDF-H5117-1mg (200ug X 5)
¥25930.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    BDNF, ANON2, BULN2, Abrineurin

  • 表达区间及表达系统(Source)

    Human BDNF Protein (E. coli), Research Grade (BDF-H5117) is expressed from E. coli cells. It contains AA His 129 - Arg 247 (Accession # P23560-1).

    Predicted N-terminus: Met

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    BDNF Structure

    This protein carries no "tag".

    The protein has a calculated MW of 13.6 kDa. The protein migrates as 15 kDa±3 kDa under reducing (R) condition, and 13 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE).

  • 内毒素(Endotoxin)

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 0.1% TFA, pH2.2 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程
  • 质量说明(Quality Description)

    ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration before lyophilization. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
    ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.

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数据展示

  • 电泳(SDS-PAGE)

    BDNF SDS-PAGE

    Human BDNF Protein (E. coli), Research Grade on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

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背景介绍

Brain-derived neurotrophic factor (BDNF) along with nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5) are members of the neurotrophin family of trophic factors. The neurotrophins play essential roles in the development, survival, and function of a wide range of neurons in both the peripheral and central nervous systems. The neurotrophins interact with two cell surface receptors, the low affinity P75 receptor and the Trk family of high affinity tyrosine kinase receptors. NGF preferentially binds TrkA, BDNF and NT4/5 bind TrkB, and NT-3 binds TrkC (and TrkA to a lesser extent).

前沿进展

 
药物研发进展
  • 英文全称:

    Brain-derived neurotrophic factor

  • 中文全称:

    脑源性神经营养因子

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    8 详情

  • 最高研发阶段:

    批准上市

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