Cynomolgus ASGR1 Protein, His Tag

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AS1-C5243-100ug
¥3675.00
AS1-C5243-1mg (500ug X 2)
¥25470.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1

  • 表达区间及表达系统(Source)

    Cynomolgus ASGR1 Protein, His Tag (AS1-C5243) is expressed from human 293 cells (HEK293). It contains AA Ser 61 - Leu 291 (Accession # XP_005582755.1).

    Predicted N-terminus: Ser 61

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    ASGR1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 28.3 kDa. The protein migrates as 37-42 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    ASGR1 SDS-PAGE

    Cynomolgus ASGR1 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • 活性(Bioactivity)-ELISA

     ASGR1 ELISA

    Immobilized Cynomolgus ASGR1 Protein, His Tag (Cat. No. AS1-C5243) at 1 μg/mL (100 μL/well) can bind Mouse Anti-Human ASGR1 antibody-4G5, Mouse IgG2b|Mouse Kappa with a linear range of 0.06-1 ng/mL (QC tested).

    Protocol

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背景介绍

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]


前沿进展

 
药物研发进展
  • 英文全称:

    Asialoglycoprotein receptor 1

  • 中文全称:

    去唾液酸糖蛋白受体-1

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床一期

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