Human Adiponectin Protein, premium grade

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货号-规格
价格
Qty.
ADQ-H5218-100ug
¥2080.00
ADQ-H5218-1mg (500ug X 2)
¥17640.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    ADIPOQ, Adiponectin, ACDC, ACRP30, APM1, GBP28

  • 表达区间及表达系统(Source)

    Human Adiponectin Protein, premium grade (ADQ-H5218) is expressed from human 293 cells (HEK293). It contains AA Lys 101 - Asn 244 (Accession # Q15848-1).

    Predicted N-terminus: Lys 101

    It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Adiponectin Structure

    This protein carries no "tag".

    The protein has a calculated MW of 16.6 kDa. The protein migrates as 16 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

    The protein is designed as a trimer.

  • 内毒素(Endotoxin)

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • 宿主核酸残留(Host Cell DNA)

    <0.02 ng/μg of protein tested by qPCR.

  • 无菌(Sterility)

    Negative

  • 支原体(Mycoplasma)

    Negative

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳(SDS-PAGE)

    Adiponectin SDS-PAGE

    Human Adiponectin Protein, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Adiponectin SEC-MALS

    The purity of Human Adiponectin Protein, premium grade (Cat. No. ADQ-H5218) is more than 90% and the molecular weight of this protein is around 44-68 kDa verified by SEC-MALS.

    Report

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背景介绍

Adiponectin is a cytokine that is secreted from adipose tissues (adipokine), which consists of a 60 amino acid (aa) N‑terminal collagenous region and a 137 aa C‑terminal C1q-like globular domain which can be cleaved by a leukocyte-derived elastase. Adiponectin is involved in a variety of physiological functions, molecular and cellular events, including lipid metabolism, energy regulation, immune response and inflammation, and insulin sensitivity and is negatively correlated with obesity, type 2 diabetes, and atherogenesis. It also has a protective effect on neurons and neural stem cells. Adiponectin can be found in three forms with different molecular weights, namely, a low molecular weight (LMW), a moderate molecular weight (MMW), and a high molecular weight (HMW) form. The various multimeric forms of Adiponectin exhibit distinct tissue specific and gender specific profiles and activities.

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