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PE-Labeled Monoclonal Anti-Human TIM-3 Antibody, Rabbit IgG (M1G07) (0.03% Proclin)

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FABm042-01-200tests (50tests X 4)
¥4000.00
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产品详情

  • 抗体来源（Source）

    Monoclonal Anti-Human TIM-3 Antibody, Rabbit IgG (M1G07) is a rabbit monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

  • 应用（Application）

    Flow Cytometry (Detection the expression of TIM-3 on Human cells).

  • 克隆号（Clone）

    M1G07

  • 种属（Species）

    Rabbit

  • 亚型（Isotype）

    Rabbit IgG | Rabbit Kappa

  • 特异性（Specificity）

    This product is a specific antibody specifically reacts with TIM-3 protein.

  • 种属反应性（Reactivity）

    Human

  • 免疫原（Immunogen）

    Purified Human TIM-3 Protein

  • 偶联（Conjugate）

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • 同型对照（Isotype Control）

    The Isotype control is sold separately and you can search for Cat. No. DNP-PFM776 for product information.

  • 推荐稀释比（Recommended Dilution）

    1:20

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in PBS, pH7.4, 0.03% Proclin300, 0.2% BSA with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 存储（Storage）

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • 运输（Shipping）

    This product is supplied and shipped with blue ice, please inquire the shipping cost.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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数据展示

  • 活性（Bioactivity）-FACS

    TIM-3 FACS

    Flow cytometric analysis of NK-92 Cells staining with PE-Labeled Monoclonal Anti-Human Tim-3 Antibody, Rabbit IgG(M1G07) (Cat. No. FABm042-01) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1e6 cells in afinal volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

前沿进展

 
药物研发进展
  • 英文全称：

    Hepatitis A virus cellular receptor 2

  • 中文全称：

    甲型肝炎病毒细胞受体2

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    21 详情

  • 最高研发阶段：

    临床三期

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