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Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11)

COADS MS
DS
  • Antibody Internalization Detection Reagent (IGG-PZF2001) monitors endocytosis in live cells
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PNU-MY2372-100ug
¥3150.00
PNU-MY2372-1mg (500ug X 2)
¥18900.00
合计0件 产品金额¥ 0
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产品详情

  • 特异性（Specificity）

    Specifically recognizes PNU.

  • 抗体来源（Source）

    Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11) is a Rabbit monoclonal antibody recombinantly expressed from HEK293 cells.

  • 克隆号（Clone）

    M1E11

  • 亚型（Isotype）

    Rabbit IgG | Rabbit Kappa

  • 偶联（Conjugate）

    Unconjugated

  • 免疫原（Immunogen）

    PNU-BSA

  • 应用（Application）

    Application
    Recommended Usage
    ELISA
    2-1000 ng/mL

  • 纯化（Purification）

    Protein A purified / Protein G purified

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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数据展示

  • 活性（Bioactivity）-ELISA

    PNU-159682 ELISA

    Immobilized Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11) (Cat. No. PNU-MY2372) at 1 μg/mL (100 μL/well) can bind ADC-PNU-159682 with a linear range of 2-125 ng/mL (QC tested).

    Protocol

  • PNU-159682 ELISA

    Serial dilutions of PNU-159682 were added into Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11) (Cat. No. PNU-MY2372): Human IgG1 Kappa Isotype Control (mAb) (Cat. No. DNP-M2) binding reactions. The half maximal inhibitory concentration (IC50) is 2.31 ng/mL (Routinely tested).

    Protocol

  • 交叉验证-Cross Verification

    PNU-159682 CROSS_VERIFICATION

    ELISA binding of Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11) (Cat. No. PNU-MY2372) with ADC-PNU-159682, Trastuzumab Deruxtecan, Sacituzumab Govitecam, Disitamab Vedotin (RC48), DM1 Antibody Human IgG and IgG1-MMAF conjugated antibody respectively.

    The coating antibody was Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11) (Cat. No. PNU-MY2372), used at 1 μg/mL concentration. The primary antibody were different payload conjugated antibodies, including ADC-PNU-159682, Trastuzumab Deruxtecan, Sacituzumab Govitecam, Disitamab Vedotin (RC48), DM1 Antibody Human IgG and IgG1-MMAF conjugated antibodies used at 0.5 μg/mL concentration. The secondary antibody was HRP conjugated Anti-Human-IgG-Fc Antibody (6F11C8), mAb (Acro, Cat. No. IGG-LY69) used at 1:10000 concentration.

    Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (M1E11) (Cat. No. PNU-MY2372) is specific to ADC-PNU-159682, and has no cross-reactivity with Trastuzumab Deruxtecan, Sacituzumab Govitecam, Disitamab Vedotin (RC48), DM1 Antibody Human IgG and IgG1-MMAF (Routinely tested).

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背景介绍

PNU-159682 is a topoisomerase II inhibitor serving as a payload for antibody-drug conjugates (ADCs). Its mechanism of action involves stabilizing the complex formed by topoisomerase II and DNA, blocking DNA repair and replication processes, and thereby inducing cancer cell apoptosis. Some ADCs containing PNU-159682 have entered the preclinical research stage, showing targeted killing activity in solid tumor models, with particularly significant effects on tumors with high topoisomerase II expression.

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