产品详情
描述/背景(Background)
Recombinant Monoclonal Anti-PD-L1 Antibody, Rabbit (5D3) is a PD-L1 primary antibody for IHC application. PD-L1, is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. PD1 expression has been observed in a variety of cancers including melanoma and non-small cell lung cancer. The interaction of PD1/PDL1 is hypothesized to be a possible mechanism for the tumor to escape immune response. A number of checkpoint blockade inhibitors including pembrolizumab and nivolumab have been developed that target the PD1/PDL1 interaction in order to allow T-cells to recognize tumor cells without being deactivated by the tumor.
产品参数(Product Specifications)
Host SpeciesRabbitIsotypeIgGClone5D3ApplicationIHCProperty1:1000StateLiquidPositive ControlHuman Tonsil TissuesClonalityMonoclonalResearch FieldCancer Drug TargetsSourceRabbitSynonymCD274, PD-L1操作步骤(Experiment Protocol)
储存(Storage)
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. The shelf life is 30 days from the date of opening.
质量管理控制体系(QMS)
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数据展示
质控样本(Control Sample)

Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelled with HCS-S240 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
肿瘤样本(Cancer Sample)



Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HCS-S240 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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