HRP conjugated Monoclonal Anti-PBD Antibody, Rabbit IgG (1M1F9)

  • Antibody Internalization Detection Reagent (IGG-PZF2001) monitors endocytosis in live cells
用户评价
货号-规格
价格
Qty.
PBD-PLMY2212-100ug
¥3675.00
PBD-PLMY2212-1mg
¥23880.00
合计0件 产品金额¥ 0

产品详情

  • 特异性(Specificity)

    Specifically recognizes PBD.

  • 抗体来源(Source)

    HRP conjugated Monoclonal Anti-PBD Antibody, Rabbit IgG (1M1F9) is a Rabbit monoclonal antibody recombinantly expressed from HEK293 cells.

  • 克隆号(Clone)

    1M1F9

  • 亚型(Isotype)

    Rabbit IgG | Rabbit Kappa

  • 偶联(Conjugate)

    HRP-Conjugated

  • 免疫原(Immunogen)

    PBD-BSA

  • 应用(Application)

    Application
    Recommended Usage
    ELISA
    1-500 ng/mL
  • 纯化(Purification)

    Protein A purified / Protein G purified

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

推荐产品

数据展示

  • 活性(Bioactivity)-ELISA

     PBD ELISA

    Immobilized Human CD19 (20-291), Fc Tag, premium grade (Cat. No. CD9-H5251) at 5 μg/mL, add Loncastuximab tesirine and then add HRP conjugated Monoclonal Anti-PBD Antibody, Rabbit IgG (1M1F9) (Cat. No. PBD-PLMY2212) at 0.5 μg/mL (QC tested).

    Protocol

用户评价
发表评论

背景介绍

Pyrrolobenzodiazepine (PBD) dimer, is a new generation of cytotoxic payload used in antibody-drug conjugates (ADCs). The PBD dimer binds to the minor groove of DNA to form effective cytotoxic DNA interstrand crosslinks, which can block cell division and kill cancer cells. This mechanism of action utilizes a completely different cellular target from that of tubulin inhibitors, as well as a different DNA damage pattern from other DNA-targeting payloads. Anti-PBD antibody is a rabbit monoclonal antibody specially reacts with PBD, which is more sensitive than mouse antibody. The anti-PBD antibody is a useful reagent in PK assay to determine conjugated antibodies.

前沿进展

 
联系我们
项目合作
查看更多项目
实验案例分析
查看更多案例分析
  • 产品基础信息
  • 产品详情
  • 推荐产品
  • 数据展示
  • 用户评价
  • 背景介绍