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Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2)

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货号-规格
价格
Qty.
CDE-M531-100ug
¥1470.00
CDE-M531-1mg
¥6300.00
合计0件 产品金额¥ 0
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产品详情

  • 抗体来源（Source）

    Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2) is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

  • 应用（Application）

    ELISA (Evaluation of levels of CD3 epsilon protein).

    Flow Cytometry (Evaluation of an epitope within the extracellular domain of CD3 epsilon protein).

  • 克隆号（Clone）

    SP34-2

  • 种属（Species）

    Mouse

  • 亚型（Isotype）

    Mouse IgG1 | Mouse lambda

  • 特异性（Specificity）

    This product is a specific antibody specifically reacts with CD3 epsilon protein.

  • 种属反应性（Reactivity）

    Human

  • 免疫原（Immunogen）

    Purified Human CD3ε Protein

  • 偶联（Conjugate）

    Unconjugated

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in PBS, pH7.4, 10% glycerol with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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数据展示

  • 活性（Bioactivity）-ELISA

    CD3 ELISA

    Immobilized Human CD3 epsilon, His Tag (Cat. No. CDE-H5223) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2) (Cat. No. CDE-M531) with a linear range of 0.4-6 ng/mL (QC tested).

    Protocol

  • 活性（Bioactivity）-FACS

    CD3 FACS

    2e5 of Jurkat cells were stained with 100 μL of 10 μg/mL of Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2) (Cat. No. CDE-M531) and isotype control antibody respectively, washed and then followed by PE-anti mouse IgG1 antibody and analyzed with FACS (Routinely tested).

    Protocol

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背景介绍

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

前沿进展

 
药物研发进展
  • 英文全称：

    T cell surface glycoprotein CD3

  • 中文全称：

    T细胞表面糖蛋白CD3复合体

  • 种类：

  • 上市药物数量：

    8 详情

  • 临床药物数量：

    177 详情

  • 最高研发阶段：

    临床二期

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