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PE-Labeled Monoclonal Anti-Human CD279 (PD-1) Antibody, Mouse IgG2b (AS630) (0.03% Proclin)

COADS MS
DS
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货号-规格
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FABm044-01-200tests (50tests X 4)
¥5500.00
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产品详情

  • 应用（Application）

    Flow Cytometry (Detection the expression of CD279 on Human cells).

  • 克隆号（Clone）

    AS630

  • 种属（Species）

    Mouse

  • 亚型（Isotype）

    Mouse IgG2b | Mouse kappa

  • 特异性（Specificity）

    This product is a specific antibody specifically reacts with CD279 protein.

  • 种属反应性（Reactivity）

    Human

  • 免疫原（Immunogen）

    Purified Human CD279 Protein

  • 偶联（Conjugate）

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • 同型对照（Isotype Control）

    The Isotype control is sold separately and you can search for Cat. No. DNP-PM486 for product information.

  • 推荐稀释比（Recommended Dilution）

    1:20

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in PBS, pH7.4, 0.03% Proclin300, 0.2% BSA with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 存储（Storage）

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • 运输（Shipping）

    This product is supplied and shipped with blue ice, please inquire the shipping cost.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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数据展示

  • 活性（Bioactivity）-FACS

    CD279 FACS

    Flow cytometric analysis of Human PD-1/LAG-3 (Luc) Jurkat Reporter cell staining with PE-Labeled Monoclonal Anti-Human CD279 (PD-1) Antibody, Mouse IgG2b (AS630) (Cat. No. FABm044-01) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

CD279, or programmed cell death protein 1 (PD-1), is a 55 kD member of the immunoglobulin superfamily with an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic region. It is mainly expressed on activated T cells, B cells and myeloid cells, and negatively regulates immune responses by binding to its ligands PD-L1 (B7-H1) and PD-L2 (B7-DC), thereby inhibiting T cell proliferation and cytokine secretion. Dysregulatio of the PD-1 pathway is linked to autoimmune diseases (e.g, rheumatoid arthritis, systemic lupus erythematosus) and tumor immune escape, makin it a key target for cancer immunotherapy. The antibody PE, anti-Human CD279 (PD-1)-AS630 binds specifically to CD279, facilitating relevant research.

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