Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1, premium grade

优势特色（Features and Advantages）

1. Seamless Transition from Preclinical to Clinical: Same cell clone, process, and QC as GMP products.
2. Enhanced Production Standards: AOF raw materials, pharma-grade excipients, Grade B+A (ISO 5) environment.
3. Comprehensive Quality Control: Additional strict testing for process impurities, sterility, and mycoplasma.
4. Cost-Effective Solution: GMP-comparable quality at an economical price for early development.
5. Risk Mitigation: Enhanced safety through rigorous impurity control and comprehensive testing.

抗体来源（Source）

Monoclonal Anti-Human 4-1BB Antibody, Mouse IgG1, premium grade (41B-CH25G1) is a chimeric monoclonal antibody recombinantly produced from CHO cells, which combines the variable region of a human monoclonal antibody with mouse IgG1 constant domain.

It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage.
GMP-M41B35 is the GMP version of this 41B-CH25G1. These two proteins display indistinguishable performance profiles, thereby ensuring a seamless transition for end users from early preclinical stage to later clinical phases.

亚型（Isotype）

Mouse IgG1 | Mouse Kappa

偶联（Conjugate）

Unconjugated

特异性（Specificity）

This product is a specific antibody specifically reacts with 4-1BB.

内毒素（Endotoxin）

Less than 0.002 EU per μg by the LAL method / rFC method.

蛋白A残留（Protein A）

<5 ppm of protein tested by ELISA.

宿主蛋白残留（Host Cell Protein）

<0.5 ng/μg of protein tested by ELISA.

宿主核酸残留（Host Cell DNA）

<0.02 ng/μg of protein tested by qPCR.

纯度（Purity）

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

无菌（Sterility）

Negative

支原体（Mycoplasma）

Negative

制剂（Formulation）

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

For long term storage, the product should be stored at liquid state at -20°C or below.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C or below for 24 months under sterile conditions;
2. 2-8°C for 12 months after thaw if within expiry date.

质量管理控制体系（QMS）

1. 质量管理体系（ISO, GMP）
2. 质量优势
3. 质控流程

质量说明（Quality Description）

ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration, followed by lyophilization where applicable. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.