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 > 【MAG / Siglec-4a】

MAG / Siglec-4a信息

英文名称:Myelin-associated glycoprotein
中文名称:髓磷脂相关糖蛋白
靶点别称:MAG,Siglec-4a,GMA,Sialic Acid Binding Ig-Like Lectin 4A,Myelin-Associated Glycoprotein,SIGLEC4A,S-MAG,SPG75,Myelin Associated Glycoprotein,Sialic Acid-Binding Immunoglobulin-Like Lectin 4A
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

MAG / Siglec-4a 分子别名

MAG,Siglec-4a,GMA,S-MAG

MAG / Siglec-4a 分子背景

Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.

MAG / Siglec-4a 前沿进展

MAG / Siglec-4a临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Refanezumab 249320; GSK-249320; 3ZZ278643V (UNII code) 葛兰素史克 详情
AXER-204 AXER-204 临床二期 Renetx Bio 心脏和血管疾病 详情

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