搜索
 > 【MERTK】

MERTK信息

英文名称:Tyrosine-protein kinase Mer
中文名称:Mer受体酪氨酸激酶
靶点别称:Tyro12,C-Eyk,C-Mer,RP38,c-Mer Tyrosine Kinase,MER,MERTK,C-Mer Proto-Oncogene Tyrosine Kinase,Receptor Tyrosine Kinase MerTK,Tyrosine-Protein Kinase Mer,EC 2.7.10.1,STK Kinase,EC 2.7.10,Proto-oncogene c-Mer,MER Proto-Oncogene, Tyrosine Kinase,MER Receptor
上市药物数量:0
临床药物数量:2
最高研发阶段:临床一期

MERTK产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
MEK-H52H6
Human
Human MERTK / Mer Protein, His Tag
MEK-H5253
Human
Human MERTK / Mer Protein, Fc Tag
MEK-M5253
Mouse
Mouse MERTK / Mer Protein, Fc Tag
MEK-C5253
Cynomolgus
Cynomolgus MERTK / Mer Protein, Fc Tag (MALS verified)
 
评论(0)
 

MERTK 分子别名

MERTK,Mer

MERTK 分子背景

Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

MERTK 前沿进展

MERTK临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
INCB-081776 INCB-81776; INCB-081776 临床一期 Incyte Corp 实体瘤 详情
MRX-2843 MRX-2843; UNC-2025; UNC-2371 临床一期 Meryx, University Of North Carolina At Chapel Hill, 科罗拉多大学丹佛分校 实体瘤, 白血病, 病理过程, 急性淋巴细胞白血病, 肿瘤形成过程, 急性髓细胞样白血病, 转移癌 详情

消息提示

请输入您的联系方式,再点击提交!

确定