NKG2D 靶点蛋白|抗体药物|临床药物信息

NKG2D信息

英文名称：NKG2-D type II integral membrane protein
中文名称：
靶点别称：Killer cell lectin-like receptor subfamily K member 1，NK cell receptor D，NKG2-D-activating NK receptor，CD314，D12S2489E，KLR，DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence，Killer Cell Lectin Like Receptor K1，NKG2-D，Killer Cell Lectin-Like Receptor Subfamily K， Member 1，KLRK1，CD314 Antigen

上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期

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在线 (8)

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Protein (8)

标记

货号	物种	产品描述
NKD-C5248	Cynomolgus	Cynomolgus NKG2D / CD314 Protein, His Tag
NKD-H5245	Human	Human NKG2D / CD314 Protein, His Tag
NKD-H5257	Human	Human NKG2D / CD314 Protein, Llama IgG2b Fc Tag, low endotoxin
NKD-H5259	Human	Human NKG2D / CD314 Protein, Mouse IgG2a Fc Tag
NKD-H5265	Human	Human NKG2D / CD314 Protein, Fc Tag (HPLC-verified)
NKD-H82E3	Human	Biotinylated Human NKG2D / CD314 Protein, His,Avitag™
NKD-H82F4	Human	Biotinylated Human NKG2D / CD314 Protein, Avitag™,Fc Tag (MALS verified)
NKD-HF224	Human	FITC-Labeled Human NKG2D / CD314 Protein, Fc Tag

NKG2D分子别名

NKG2D,CD314,KLRK1,NK cell receptor D

NKG2D分子背景

NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.

NKG2D临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Tesnatilimab	IPH-2301; IPH-23XX; JNJ-4500; JNJ-64304500; NNC-0142-002; NNC-0142-0002; NNC-0142-0000-0002; NN-8555	临床二期	Innate Pharma	斑秃, 类风湿关节炎, 乳糜泻, 炎性疾病, 克罗恩病	详情
NKG2D CAR-T Cell therapy (Yake Biotechnology)		临床一期	上海雅科生物科技有限公司	结直肠癌, 急性髓细胞样白血病	详情
NKG2D-ACE2 CAR-NK cell therapy (Sidemu Biotechnology Technology)		临床二期	重庆赛德姆生物科技有限公司	新型冠状病毒肺炎	详情
NKG2D CAR-T cell therapy (Uwell Biopharma)	UWN2D	临床阶段不明	Uwell Biopharma	肿瘤	详情

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NKG2D

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