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> 【NKG2D】
NKG2D信息
英文名称：NKG2-D type II integral membrane protein
中文名称：
靶点别称：Killer cell lectin-like receptor subfamily K member 1，NK cell receptor D，NKG2-D-activating NK receptor，CD314，D12S2489E，KLR，DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence，Killer Cell Lectin Like Receptor K1，NKG2-D，Killer Cell Lectin-Like Receptor Subfamily K， Member 1，KLRK1，CD314 Antigen
中文名称：
靶点别称：Killer cell lectin-like receptor subfamily K member 1，NK cell receptor D，NKG2-D-activating NK receptor，CD314，D12S2489E，KLR，DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence，Killer Cell Lectin Like Receptor K1，NKG2-D，Killer Cell Lectin-Like Receptor Subfamily K， Member 1，KLRK1，CD314 Antigen
上市药物数量：0
临床药物数量：3
最高研发阶段：临床二期
临床药物数量：3
最高研发阶段：临床二期
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NKG2D 分子别名
NKG2D,CD314,KLRK1,NK cell receptor D
NKG2D 分子背景
NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.
NKG2D 前沿进展
NKG2D临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| NKG2D CAR-T Cell therapy (Yake Biotechnology) | 临床一期 | 上海雅科生物科技有限公司 | 急性髓细胞样白血病 | 详情 | |
| NKG2D CAR-T cell therapy (Uwell Biopharma) | UWN2D | 临床阶段不明 | Uwell Biopharma | 肿瘤 | 详情 |
| Tesnatilimab | IPH-2301; IPH-23XX; JNJ-4500; JNJ-64304500; NNC-0142-002; NNC-0142-0002; NNC-0142-0000-0002; NN-8555 | 临床二期 | Innate | 斑秃, 类风湿关节炎, 乳糜泻, 炎性疾病, 克罗恩病 | 详情 |
