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Siglec-8信息

英文名称:Sialic acid-binding Ig-like lectin 8
中文名称:唾液酸结合免疫球蛋白样凝集素-8
靶点别称:Sialic acid-binding Ig-like lectin 8,SIGLEC8,SAF2,Sialoadhesin family member 2,SAF-2,Sialic Acid Binding Ig Like Lectin 8,Sialic Acid Binding Ig-Like Lectin 8,SIGLEC8L,Siglec-8,MGC59785
上市药物数量:0
临床药物数量:2
最高研发阶段:临床三期

Siglec-8 分子别名

Siglec-8,SAF-2,SIGLEC8,SAF2

Siglec-8 分子背景

Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-8 前沿进展

Siglec-8临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Lirentelimab AK-002 临床三期 Allakos Inc 嗜酸细胞性胃肠炎(EG), 系统性肥大细胞增多症, 慢性荨麻疹, 嗜酸性粒细胞性食管炎, 变应性结膜炎, 十二指肠炎, 角结膜炎, 特应性皮炎 详情
AK-001 AK-001 临床三期 Allakos Inc 呼吸道感染, 鼻息肉, 泌尿系统感染, 社区获得性肺炎, 特应性皮炎 详情

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