Glypican 2 靶点蛋白|抗体药物|临床药物信息

Glypican 2信息

英文名称：Glypican-2
中文名称：磷脂酰肌醇蛋白2
靶点别称：Cerebroglycan，Glypican Proteoglycan 2， Cerebroglycan Proteoglycan

上市药物数量：0
临床药物数量：1
最高研发阶段：临床一期

Glypican 2产品列表

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在线 (4)

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属性

Protein (4)

标记

Unconjugated (4)

货号	物种	产品描述
GP2-H52H3	Human	Human Glypican 2 / GPC2 Protein, His Tag
GP2-M52H5	Mouse	Mouse Glypican 2 / GPC2 Protein, His Tag
GP2-R52H9	Rhesus macaque	Rhesus macaque Glypican 2 / GPC2 Protein, His Tag
GP2-H5255	Human	Human Glypican 2 / GPC2 Protein, Fc Tag (SPR verified)

Glypican 2 分子别名

Glypican 2,GPC2

Glypican 2 分子背景

Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.

Glypican 2 前沿进展

Glypican 2临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
GPC2 CAR-T cell therapy(Childrens Hospital of Philadelphia/Tmunity Therapeutics)	TmGPC2-01-CAR-T	临床一期	The Children'S Hospital Of Philadelphia	小细胞肺癌, 膀胱癌, 神经母细胞瘤	详情

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Glypican 2