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EGFRvIII信息

英文名称:Epidermal growth factor receptor variant III
中文名称:表皮生长因子受体变体III
靶点别称
上市药物数量:0
临床药物数量:7
最高研发阶段:临床二期

EGFRvIII产品列表

 
评论(1)
EGI-HP2E3|PE-Labeled Human EGFRvIII Protein, His Tag (Site-specific conjugation)
  1. 151XXXXXXX5
  2. 0人赞
  3. 购买蛋白是为了做biacore实验,实验发现蛋白的亲和力很好,做出来的结果也很符合理论,实验非常成功,蛋白非常好?
  4. 2021-12-06
 

EGFRvIII 分子别名

EGFRvIII

EGFRvIII 分子背景

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.The type III EGF deletion-mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors; EGFR gene amplification is correlated with the structural rearrangement of the gene. The EGFRvIII gene has an in-frame deletion of 801 base pairs, corresponding to exons 2–7 in the mRNA, resulting in the deletion of amino acids 30-297 in the extracellular domain and the generation of a glycine at the fusion point

EGFRvIII 前沿进展

EGFRvIII临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Anti-EGFRvIII-CAR EGFRvIII CAR; Anti-EGFRvIII-CAR 临床二期 美国国立癌症研究所, Kite Pharma 胶质母细胞瘤 详情
EGFRvIII-CAR 临床一期 杜克大学医学中心 胶质母细胞瘤 详情
Recombinant anti-EGFR chimeric monoclonal antibody (Shanghai CP Guojian) CPGJ-602; 602; CPGJ602; CPGJ 602 临床二期 三生国健药业(上海)股份有限公司 结直肠癌 详情
EGFRvIII Targeted Chimeric Antigen Receptor CAR-T Cell Therapy (Chembrain) 临床一期 Chembrain Ltd 胶质母细胞瘤, 胶质瘤 详情
EGFRvIII-directed CAR-T cell tharapy (Novartis/University of Pennsylvania) LXF-821 临床一期 宾夕法尼亚大学, 诺华制药 胶质母细胞瘤 详情
Etevritamab AMG-596 临床一期 安进 胶质母细胞瘤 详情
hEGFRvIII-CD3 Bi-scFv 临床一期 杜克大学 胶质母细胞瘤, 胶质瘤 详情
GNC-039 GNC-039 临床一期 四川百利药业有限责任公司 实体瘤, 血液肿瘤, 胶质瘤, 转移癌 详情

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