LRP-5 靶点蛋白|抗体药物|临床药物信息

LRP-5信息

英文名称：Low-density lipoprotein receptor-related protein 5
中文名称：低密度脂蛋白受体相关蛋白5
靶点别称：

上市药物数量：0
临床药物数量：2
最高研发阶段：临床一期

LRP-5产品列表

筛选结果

产品库

在线 (2)

物种

Human (2)

标签

属性

Protein (2)

标记

货号	物种	产品描述	蛋白结构	纯度	活性
LR5-H5254	Human	Human LRP-5 Protein, Mouse IgG2a Fc Tag
LR5-H82E6	Human	Biotinylated Human LRP-5 Protein, His,Avitag™

LR5-H5254|Human LRP-5 Protein, Mouse IgG2a Fc Tag

188XXXXXXX8

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2022-11-25

LRP-5 分子别名

LRP5,LRP-5,LRP-7,LRP7,LR3

LRP-5 分子背景

Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

LRP-5 前沿进展

LRP-5临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
BI-905681	BI-905681	临床一期	Boehringer Ingelheim Ltd	肿瘤	详情
BI-905677	BI-905677	临床一期	勃林格殷格翰	肿瘤	详情

会议日历

会议一览

LRP-5