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LRP-5产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
LR5-H5254
Human
Human LRP-5 Protein, Mouse IgG2a Fc Tag
LR5-H82E6
Human
Biotinylated Human LRP-5 Protein, His,Avitag™
 
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LRP-5 分子别名

LRP5,LRP-5,LRP-7,LRP7,LR3

LRP-5 分子背景

Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

LRP-5 前沿进展

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