IL-8 靶点蛋白|抗体药物|临床药物信息

IL-8信息

英文名称：Interleukin-8
中文名称：白细胞介素-8
靶点别称：IL8/NAP1 form VI，T-cell chemotactic factor，GCP/IL-8 protein III，IL8/NAP1 form II，GCP/IL-8 protein II，(Ala-IL-8)77，Emoctakin，IL8/NAP1 form IV，LYNAP，IL8/NAP1 form III，IL8/NAP1 form V，GCP/IL-8 protein I，Neutrophil-Activating Peptide 1，Interleukin 8，GCP-1，MDNCF，NAP-1，IL8，Beta Endothelial Cell-Derived Neutrophil Activating Peptide，Lung Giant Cell Carcinoma-Derived Chemotactic Protein，Lymphocyte Derived Neutrophil Activating Peptide，Alveolar Macrophage Chemotactic Factor I，Tumor Necrosis Factor-Induce

上市药物数量：1
临床药物数量：5
最高研发阶段：批准上市

IL-8产品列表

筛选结果

产品库

物种

标签

属性

标记

货号	物种	产品描述
IL8-H52H3	Human	Human IL-8 / CXCL8 Protein, His Tag
IL8-H5258	Human	Human IL-8 / CXCL8 Protein, Fc Tag
IL8-C52H3	Cynomolgus	Cynomolgus IL-8 / CXCL8 Protein, His Tag
IL8-H82H3	Human	Biotinylated Human IL-8 protein, His,Avitag™
CRS-A007	Human	Human Interleukin-8(IL-8) ELISA Kit
CEA-C004	Human	ClinMax™ Human IL-8 ELISA Kit
IL8-C52H4	Cynomolgus	Cynomolgus IL-8 / CXCL8 Protein, His Tag (MALS verified)

IL-8 分子别名

CXCL8,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1

IL-8 分子背景

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

IL-8 前沿进展

IL-8上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Mouse monoclonal antibody against human interleukin-8 cream	抗人白介素-8鼠单抗乳膏		批准上市	大连亚维药业有限公司, 东莞宏远逸士生物技术药业有限公司	恩博克	Mainland China	湿疹, 银屑病	Dalian Asia Space Pharmaceutical Co Ltd	2001-04-10	银屑病, 湿疹	详情

IL-8临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
AC-701	AC-701	临床二期	安成国际药业股份有限公司	酒渣鼻, 皮疹	详情
Ensereptide	PXL-01	临床三期	Promore Pharma	术后黏连, 瘢痕	详情
HuMax-IL8	MDX-018; BMS-986253	临床二期	Medarex, Genmab, 百时美施贵宝	实体瘤, 血液肿瘤, 肾细胞癌, 头颈部鳞状细胞癌, 新型冠状病毒肺炎, 前列腺癌, 黑色素瘤, 肝细胞癌, 非小细胞肺癌	详情

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IL-8