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PSCA信息

英文名称:Prostate stem cell antigen
中文名称:前列腺干细胞抗原
靶点别称:Prostate stem cell antigen,UNQ206/PRO232,PSCA,PRO232
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

PSCA 分子别名

PSCA,UNQ206,PRO232

PSCA 分子背景

The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored protein, plays an important role in tumorigenesis. The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.

PSCA 前沿进展

PSCA临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BPX-601 BPX-601 临床二期 Bellicum 胰腺癌, 膀胱癌, 前列腺癌, 食道腺癌, 胰腺导管癌 详情
124-iodine-labeled PSCA targeting minibody (ImaginAb) 临床一期 加州大学洛杉矶分校 胰腺癌, 膀胱癌, 前列腺癌 详情
GEM3-PSCA GEM3-PSCA 临床一期 Gemoab Monoconals, Gcp Service International 肾肿瘤, 移行细胞癌, 胰腺癌, 前列腺癌, 乳腺癌, 非小细胞肺癌 详情

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